Mariana Gerschenson, Ph.D.
Professor and Associate Dean for Research
Center for Cardiovascular Research
John A. Burns School of Medicine
651 Ilalo Street, BSB 311
Honolulu, HI 96813
Email: gerschen@hawaii.edu
Phone: (808) 692-1518
Molecular Cardiovascular Pathophysiology in HIV-infected Patients
Besides comprehensive diabetes research programs conducted through the Diabetes Research Center project (COBRE-Diabetes; 2P20GM113134; PI), Dr. Gerschenson studies the associations between chronic inflammation and mitochondrial abnormalities with echocardiographic and biomarkers in perinatally HIV-infected adolescents and young adults. Efforts is also focused on dissecting epigenetic dysregulations in these patients. These projects will help identify novel biomarkers of subclinical cardiac abnormalities and for informing public health policy and the design of future intervention trials aimed at optimizing cardiovascular health across the lifespan in children living with HIV.
Funding: Epigenetic dysregulation of inflammation linked to longitudinal cardiac toxicity in perinatal HIV infection (5R21AI170252; Co-PI)